Cost evaluation of antibody production processes in different operation modes
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- 作者：Stephan Klutza ; 1 ; Laura Holtmanna ; 1 ; holtmann@invite-research.com" class="auth_mail" title="E-mail the corresponding author ; Martin Lobedanna ; Gerhard Schembeckerb
- 关键词：AEX ; Anion exchange chromatography ; B/E mode ; Bind and elude mode ; C ; Continuously operated process ; CoG ; Cost of goods ; CSPR ; Cell-specific perfusion rate ; CSTR ; Continuous stirred tank reactor ; DSP ; Downstream process ; FB ; Fed-batch process ; FTE ; Full time employees ; GMP ; Good manufacturing practice ; mAb ; Monoclonal antibody ; HIC ; Hydrophobic interaction chromatography ; MU ; Multiuse ; PAC ; Protein A chromatography ; PCC ; Periodic counter-current chromatography ; QC/QA ; Quality control/quality ass
- 刊名：Chemical Engineering Science
- 出版年：2016
- 出版时间：17 February 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：63-74
- 全文大小：2350 K
文摘
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Economic evaluation of a platform process in three different operation modes.
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Presentation of detailed cost structures of three different operation modes.
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Identification of the main cost contributors in all process modes.
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Identification of the hybrid process mode as the most cost efficient operation mode.
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Identification of benefits and limitations in continuous antibody processing.