Role of melanin in the pathogenesis of cutaneous sporotrichosis
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- 作者：Isabel Martins Madrid ; Melissa O. Xavier ; Antonella S. Mattei ; Cristina G. Fern ; es ; Thomaz N. Guim ; Rosema Santin ; Luiz Filipe D. Schuch ; Má ; rcia de Oliveira Nobre ; Má ; rio Carlos Araú ; jo M
- 关键词：Sporothrix schenckii ; Melanin ; Virulence factors
- 刊名：Microbes and Infection
- 出版年：2010
- 出版时间：February 2010
- 年：2010
- 卷：12
- 期：2
- 页码：162-165
- 全文大小：662 K
文摘
In this study, we evaluate the clinical, histopathological and ultra structural aspects of the infection by field strain (MEL+) and mutated strain (MEL−) of Sporothrix schenckii. The development of sporotrichosis at the inoculation sites was similar for both groups of animals after the second week of the experimental period. Statistical differences appeared only at weeks 3 and 5. The pigmented isolate had greater tissue invasive capacity, promoting the formation of multifocal granulomas, whereas the albino isolate induced an enhanced inflammatory response, restraining the agent to the core of the granulomas.