PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells
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- 作者：Davide Schiavone1 ; 3 ; Stanislaw K. Jozwiakowski2 ; 3 ; Marina Romanello1 ; Guillaume Guilbaud1 ; Thomas A. Guilliam2 ; Laura J. Bailey2 ; Julian E. Sale1 ; jes@mrc-lmb.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Aidan J. Doherty2 ; ajd21@sussex.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：PrimPol ; polymerase ; primase ; replication stalling ; G quadruplexes ; TLS ; repriming ; epigenetic instability
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 January 2016
- 年：2016
- 卷：61
- 期：1
- 页码：161-169
- 全文大小：2392 K
文摘
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G4s block replication in cells lacking PrimPol causing local epigenetic instability
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PrimPol binds G4s but cannot directly replicate them
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PrimPol reprimes DNA synthesis closely coupled to G4s
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Repriming preserves epigenetic stability in proximity G4 sequences