Transcriptome analysis reveals that up-regulation of the fatty acid synthase gene promotes the accumulation of docosahexaenoic acid in Schizochytrium sp. S056 when glycerol is used
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- 作者：Wei Chena ; b ; c ; 1 ; Peng-peng Zhoua ; b ; c ; 1 ; Meng Zhanga ; b ; Yuan-min Zhua ; b ; c ; Xiao-peng Wanga ; b ; c ; Xin-an Luoa ; b ; c ; Zhen-dong Baoa ; Long-jiang Yua ; b ; c ; yulongjiang@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Schizochytrium sp. ; Docosahexaenoic acid ; Glycerol ; Transcriptome analysis ; Fatty acid synthase ; Acetyl-CoA
- 刊名：Algal Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：15
- 期：Complete
- 页码：83-92
- 全文大小：1093 K
文摘
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Glycerol increased the production of DHA.
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The effect of carbon source on DHA biosynthesis was studied by transcriptome analysis.
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Glycolysis and val-leu-ile metabolism were substantially up-regulated by glycerol.
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TCA cycle downregulation increased acetyl-CoA source for fatty acid biosynthesis.
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Overexpression of the FAS gene favors the accumulation of DHA.