A high-mobility group box 1 that binds to DNA, enhances pro-inflammatory activity, and acts as an anti-infection molecule in black rockfish, Sebastes schlegelii
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- 作者：Zhao Xin-penga ; Hu Yong-huab ; Liu Yonga ; Wang Jing-jinga ; Wang Guang-huaa ; Wang Ren-jiea ; Zhang Mina ; lissazhang06@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sebastes schlegelii ; High-mobility group box 1 ; DNA binding ; Immunoregulation ; Antibacterial
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：402-409
- 全文大小：1504 K
文摘
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A HMGB1 homologue (SsHMGB1) was identified and characterized.
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Expression of SsHMGB1 in macrophages could be induced by Listonella anguillarum.
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Recombinant SsHMGB1 purified from E. coli was able to bind with DNA fragments.
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Recombinant SsHMGB1 possesses apparent immunoregulatory property and is likely to be involved in anti-bacterial infection.