Interaction of vectors and parental viruses with the host genome

详细信息    查看全文

• 作者：Irene Gil-Farina ; Manfred Schmidt ^{manfred.schmidt@nct-heidelberg.de}
• 刊名：Current Opinion in Virology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：21
• 期：Complete
• 页码：35-40
• 全文大小：736 K
• 卷排序：21

文摘

Nuclear architecture and nuclear pore trafficking strongly influence HIV integration. wtAAV integration targets genomic regions bearing a Rep binding site and trs motif. No genotoxic events have been reported in lentiviral and AAV vectors clinical studies.