Current Results of Surgical Aortic Valve Replacement: Insights From the German Aortic Valve Registry

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• 作者：David Holzhey ; MD ; PhD^a ; ^{dholzhey@web.de" class="auth_mail" title="E-mail the corresponding author} ; Friedrich W. Mohr ; MD ; PhD^a ; Thomas Walther ; MD ; PhD^b ; Helge Mö ; llmann ; MD ; PhD^b ; Andreas Beckmann ; MD ; PhD^c ; Joachim Kö ; tting ; MS^d ; Hans Reiner Figulla ; MD ; PhD^e ; Jochen Cremer ; MD ; PhD^f ; Karl-Heinz Kuck ; MD ; PhD^g ; Rü ; diger Lange ; MD ; PhD^h ; Stefan Sack ; MD ; PhDⁱ ; Gerhard Schuler ; MD ; PhD^a ; Friedhelm Beyersdorf ; MD ; PhD^j ; Michael Bö ; hm ; MD ; PhD^k ; Gerd Heusch ; MD ; PhD^l ; Thomas Meinertz ; MD ; PhD^m ; Till Neumann ; MD ; PhDⁿ ; Konstantinos Papoutsis ; MD ; PhD^o ; Steffen Schneider ; PhD^p ; Armin Welz ; MD ; PhD^q ; Christian W. Hamm ; MD ; PhD^b
• 刊名：The Annals of Thoracic Surgery
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：101
• 期：2
• 页码：658-666
• 全文大小：643 K

文摘

Conventional aortic valve replacement (AVR) remains the therapy of choice for many patients with severe aortic valve disease. The unique German Aortic Valve Registry (GARY) allows the comparison of contemporary outcomes of AVR with those of transcatheter AVRs. We report here real-world, all-comers outcomes of AVR, including combined AVR and coronary bypass grafting (AVR+CABG).

Methods

A total of 34,063 patients who received AVR (22,107 patients, 39% female; mean age 68.0 ± 11.3 years, mean logistic European System for Cardiac Operative Risk Evaluation, 8.6%) or AVR+CABG (11,956 patients, 28% female; mean age 72.6 ± 7.8 years, mean logistic European System for Cardiac Operative Risk Evaluation, 10.7%) between 2011 and 2013 were analyzed and followed up to assess the 1-year outcome.

Results

In-hospital mortality was 2.3% for AVR and 4.1% for AVR+CABG. Other important outcome variables include stroke (AVR, 1.2%; AVR+CABG, 1.9%) and new pacemaker implantation (AVR, 4.4%; AVR+CABG, 3.6%). Survival at 1 year was 93.2% for AVR and 89.4% for AVR+CABG. Total stroke rates at 1 year were 1.6% for AVR and 2.0% AVR+CABG. Quality of life assessment indicated that most patients were in New York Heart Association Functional Classification I or II (AVR, 86%; AVR+CABG, 84%) and that they were satisfied with the overall postoperative course (AVR, 88%; AVR+CABG, 87%).

Conclusions

Contemporary surgical AVR yields excellent outcomes with low in-hospital mortality, a low overall complication rate, and good 1-year outcome for all risk groups. Accordingly, conventional AVR remains an important therapeutic option for many patients.