Fabrication of nitric oxide-releasing polyurethane glucose sensor membranes

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• 作者：Ahyeon  ; Koh ; Daniel A.  ; Riccio ; Bin  ; Sun ; Alexis W.  ; Carpenter ; Scott P.  ; Nichols ; Mark H.  ; Schoenfisch  ; ;   ; ^{schoenfisch@unc.edu}
• 关键词：Nitric oxide release ; Glucose biosensor ; Polyurethane membrane
• 刊名：Biosensors and Bioelectronics
• 出版年：2011
• 出版时间：15 October 2011
• 年：2011
• 卷：28
• 期：1
• 页码：17-24
• 全文大小：329 K

文摘

Despite clear evidence that polymeric nitric oxide (NO) release coatings reduce the foreign body response (FBR) and may thus improve the analytical performance of in vivo continuous glucose monitoring devices when used as sensor membranes, the compatibility of the NO release chemistry with that required for enzymatic glucose sensing remains unclear. Herein, we describe the fabrication and characterization of NO-releasing polyurethane sensor membranes using NO donor-modified silica vehicles embedded within the polymer. In addition to demonstrating tunable NO release as a function of the NO donor silica scaffold and polymer compositions and concentrations, we describe the impact of the NO release vehicle and its release kinetics on glucose sensor performance.