Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing
详细信息 查看全文
- 作者：Holger Bierhoff1 ; Marcel Andre Dammert1 ; David Brocks1 ; Silvia Dambacher2 ; Gunnar Schotta2 ; Ingrid Grummt1 ; i.grummt@dkfz.de" class="auth_mail
- 刊名：Molecular Cell
- 出版年：22 May 2014
- 年：2014
- 卷：54
- 期：4
- 页码：675-682
- 全文大小：1434 K
文摘
- •
PAPAS, a lncRNA in antisense orientation to rDNA, is upregulated in quiescent cells
- •
PAPAS interacts with Suv4-20h2 and mediates H4K20me3 at rDNA
- •
H4K20me3 induces global chromatin compaction upon quiescence
- •
LncRNAs mediate H4K20me3 and chromatin compaction at IAP retrotransposons