Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking
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- 作者：Takako Sasakia ; b ; tsasaki@oita-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Reinout Stoopc ; Takao Sakaid ; Andreas Hesse ; Rainer Deutzmannf ; Ursula Schlö ; tzer-Schrehardtg ; Mon-Li Chuh ; Klaus von der Marka
- 关键词：cbEGF ; calcium-binding epidermal growth factor ; FC ; fibulin-type C-terminal ; LOX ; lysyl oxidase ; wt ; wild type ; LP ; lysylpridinoline/deoxypyridinoline ; HP ; hydroxylysylpridinoline/prydinoline ; Lys ; lysine ; Hyl ; hydroxylysine ; BAPN ; β-aminopropionitrile
- 刊名：Matrix Biology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：50
- 期：Complete
- 页码：53-66
- 全文大小：2442 K
文摘
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Fibulin-4 deficiency results in abnormal collagen fibrillogenesis in bone.
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Collagen cross-links in bone are reduced in fibulin-4 deficient mice.
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Fibulin-4 plays a role in proteolytic activation of lysyl oxidase.