Bordetella holmesii: an under-recognised Bordetella species

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• 作者：Laure F Pittet ; MD^a ; Sté ; phane Emonet ; MD^b ; Prof Jacques Schrenzel ; MD^b ; Prof Claire-Anne Siegrist ; MD^a ; ^c ; Dr Klara M Posfay-Barbe ; MD^a ; ^{klara.posfaybarbe@hcuge.ch" class="auth_mail}
• 刊名：The Lancet Infectious Diseases
• 出版年：June 2014
• 年：2014
• 卷：14
• 期：6
• 页码：510-519
• 全文大小：2117 K

文摘

Bordetella holmesii, first described in 1995, is believed to cause both invasive infections (bacteraemia, meningitis, endocarditis, pericarditis, pneumonia, and arthritis) and pertussis-like symptoms. Infection with B holmesii is frequently misidentified as being with B pertussis, the cause of whooping cough, because routine diagnostic tests for pertussis are not species-specific. In this Review, we summarise knowledge about B holmesii diagnosis and treatment, and assess research needs. Although no fatal cases of B holmesii have been reported, associated invasive infections can cause substantial morbidities, even in previously healthy individuals. Antimicrobial treatment can be problematic because B holmesii's susceptibility to macrolides (used empirically to treat B pertussis) and third-generation cephalosporins (often used to treat invasive infections) is lower than would be expected. B holmesii's adaptation to human beings is continuing, and virulence might increase, causing the need for better diagnostic assays and epidemiological surveillance.