MUC1 can interact with adenomatous polyposis coli in breast cancer

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• 作者：Hattrup ; Christine L. ; Fernandez-Rodriguez ; Julia ; Schroeder ; Joyce A. ; Hansson ; Gunnar C. ; et. al.
• 关键词：MUC1 ; APC ; Breast cancer ; Mammary gland
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2004
• 出版时间：April 2, 2004
• 年：2004
• 卷：316
• 期：2
• 页码：364-369
• 全文大小：1.09 M

文摘

The MUC1 tumor antigen is overexpressed on most breast tumors and metastases. It interacts with signaling proteins such as the ErbB kinases and β-catenin, and is involved in mammary gland oncogenesis and tumor progression. Herein, we report a novel interaction between MUC1 and adenomatous polyposis coli (APC), a tumor suppressor involved in downregulating β-catenin signaling. Initially identified in colorectal cancer, APC is also downregulated in breast tumors and presumably involved in mammary carcinogenesis. MUC1 and APC co-immunoprecipitate from the ZR-75-1 human breast carcinoma cell line and co-localize in mouse mammary glands and tumors. These studies also indicate that the association of MUC1 and APC may be increased by epidermal growth factor stimulation. Intriguingly, the co-immunoprecipitation of MUC1 and APC increases in human breast tumors and metastases as compared to adjacent normal tissues, indicating that this association may play a role in the formation and progression of breast tumors.