- 作者：Nicolas F. Schroten ; Willem P.T. Ruifrok ; Lennaert Kleijn ; Martin M. Dokter ; Herman H. Sillj¨¦ ; Hiddo J. Lambers Heerspink ; Stephan J.L. Bakker ; Ido P. Kema ; Wiek H. van Gilst ; Dirk J. van Veldhuisen ; Hans L. Hillege ; Rudolf A. de Boer
- 刊名：American Heart Journal
- 出版年：2013
- 出版时间：August, 2013
- 年：2013
- 卷：166
- 期：2
- 页码：357-364.e2
- 全文大小：345 K
Background
Many chronic heart failure (CHF) patients have low vitamin D (VitD) and high plasma renin activity (PRA), which are both associated with poor prognosis. Vitamin D may inhibit renin transcription and lower PRA. We investigated whether vitamin D3 (VitD3) supplementation lowers PRA in CHF patients.Methods and Results
We conducted a single-center, open-label, blinded end point trial in 101 stable CHF patients with reduced left ventricular ejection fraction. Patients were randomized to 6 weeks of 2,000 IU oral VitD3 daily or control. At baseline, mean age was 64 ¡À 10 years, 93 % male, left ventricular ejection fraction 35 % ¡À 8 % , and 56 % had VitD deficiency. The geometric mean (95 % CI) of 25-hydroxyvitamin D3 increased from 48 nmol/L (43-54) at baseline to 80 nmol/L (75-87) after 6 weeks in the VitD3 treatment group and decreased from 47 nmol/L (42-53) to 44 nmol/L (39-49) in the control group (P < .001). The primary outcome PRA decreased from 6.5 ng/mL per hour (3.8-11.2) to 5.2 ng/mL per hour (2.9-9.5) in the VitD3 treatment group and increased from 4.9 ng/mL per hour (2.9-8.5) to 7.3 ng/mL per hour (4.5-11.8) in the control group (P = .002). This was paralleled by a larger decrease in plasma renin concentration in the VitD3 treatment group compared to control (P = .020). No significant changes were observed in secondary outcome parameters, including N-terminal pro-B-type natriuretic peptide natriuretic peptide and fibrosis markers.
Conclusions
Most CHF patients had VitD deficiency and high PRA levels. Six weeks of supplementation with 2,000 IU VitD3 increased 25-hydroxyvitamin D3 levels and decreased PRA and plasma renin concentration.