A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation
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- 作者：Mahima Swamy1 ; 2 ; 3 ; 9 ; Katharina Beck-Garcia1 ; 2 ; 4 ; 9 ; Esmeralda Beck-Garcia1 ; 2 ; 5 ; Frederike A. Hartl1 ; Anna Morath1 ; 4 ; O. Sascha Yousefi1 ; 4 ; Elaine Pashupati Dopfer2 ; Eszter Molná ; r1 ; Anna K. Schulze6 ; 7 ; Raquel Blanco8 ; Aldo Borroto8 ; Nadia Martí ; n-Blanco8 ; Balbino Alarcon8 ; Thomas Hö ; fer6 ; 7 ; Susana Minguet1 ; 2 ; 10 ; Wolfgang W.A. Schamel1 ; 2 ; 10 ; wolfgang.schamel@biologie.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：44
- 期：5
- 页码：1091-1101
- 全文大小：2457 K
文摘
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TCRs can spontaneously switch from the resting to the active conformation.
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Cholesterol binding to TCRβ prevents the switching to the active conformation.
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Only in the active conformation can TCRs be phosphorylated.
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The active conformation can signal without antigen.