The V-ATPase: small cargo, large effects

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• 作者：Karin Schumacher ; Melanie Krebs
• 刊名：Current Opinion in Plant Biology
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：13
• 期：6
• 页码：724-730
• 全文大小：258 K

文摘

About 30 years ago seminal reports of anion-sensitive proton-pumping activity associated with microsomal membranes initiated research on the plant vacuolar-type H⁺-ATPase (V-ATPase, VHA). Since, it has been firmly established that these complex molecular machines are essential for what can be defined as cellular logistics. In a eukaryotic cell, the flow of goods between compartments is achieved either by protein-mediated membrane transport or via vesicular trafficking. Over the past years, it has become increasingly clear that V-ATPases do not only energize secondary active transport but are also important regulators of membrane trafficking.