A Tumor Suppressor SIRTainty

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• 作者：Paul T. Schumacker
• 刊名：Cancer Cell
• 出版年：2010
• 出版时间：19 January 2010
• 年：2010
• 卷：17
• 期：1
• 页码：5-6
• 全文大小：145 K

文摘

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.