SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

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• 作者：Paul  ; T. Schumacker¹ ; ^{p-schumacker@northwestern.edu}
• 刊名：Cancer Cell
• 出版年：2011
• 出版时间：8 March 2011
• 年：2011
• 卷：19
• 期：3
• 页码：299-300
• 全文大小：79 K

文摘

In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype.