Regulatory T cells and IL-10 levels are reduced in patients with vulnerable coronary plaques

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• 作者：Jacob George^a ; ¹ ; ^{jacobg@post.tau.ac.il} ; ^{jgeorge@bezeqint.net} ; Shmuel Schwartzenberg^a ; ¹ ; Diego Medvedovsky^b ; Michael Jonas^a ; Gideon Charach^a ; Arnon Afek^b ; Ari Shamiss^b
• 关键词：T regulatory cells ; IL-10 ; Inflammation ; Atherosclerosis ; Vulnerable plaque ; Acute coronary syndrome
• 刊名：Atherosclerosis
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：222
• 期：2
• 页码：519-523
• 全文大小：288 K

文摘

Background

Despite having a similar large extent of atherosclerotic coronary affliction, some patients suffer of recurrent cardiac events, whereas others remain asymptomatic.

Hypothesis

We hypothesized the existence of a systemic ¡°signature?that could distinguish ¡°vulnerable?patients with preexisting coronary atherosclerosis from those having similar risk factors and atheromatous burden, but no history of clinically evident plaque rupture/erosion.

Methods

Twenty three patients who had at least two prior myocardial infarctions (¡°vulnerable group? were matched in respect to their background and coronary atherosclerosis extent with twenty one patients without a history of previous myocardial infarction who underwent routine coronary angiography before valvular surgery. We studied a panel of cytokines, antibodies and hormones including IL-6, IL-10, IL-12, antibodies to ¦Â2 glycoprotein I (¦Â2GPI), antibodies to oxidized-LDL, adiponectin and resistin, along with levels of circulating EPCs and Tregs.

Results

A significantly higher level of Treg cells was present in the control (73.4 %  ¡À 4) than in the ¡°vulnerable patient?group (62.2 %  ¡À 10.7), p < 0.001. IL-10 level was also significantly higher in the control than in the vulnerable patients (2.6 ¡À 1.2 pg/ml versus 0.9 ¡À 0.1 pg/ml respectively, p = 0.03). There was no significant difference in the circulating levels of the other cytokines, hormones or EPCs between the two groups.

Conclusion

Regulatory T cells and serum IL-10 may discriminate ¡°vulnerable?versus stable patients and may have a protective role against plaque rupture in patients with coronary atherosclerosis.