A fabricated PLGA tubes pre-coated with Nectin-like molecule 1 (NECL1) strategy for sciatic nerve regeneration is proposed.
The NECL1 coated PLGA can promote Schwann cells adhesion and growth meanwhile maintain the phenotype cultured in vitro.
PLGA/NECL1 tubes bridging the nerve defect can greatly enhance the functional recovery of nerve regeneration in vivo.
The novel blend of PLGA/NECL1 conduits would be a candidate in biomedicine for tissue engineering scaffold.