Further development of an in vitro model for studying the penetration of chemicals through compromised skin

详细信息    查看全文

• 作者：Diane J Davies^a ; Jon R Heylings^a ; ^{j.heylings@dermaltechnology.com} ; Heather Gayes^a ; Timothy J McCarthy^b ; M Catherine Mack^b
• 关键词：ER ; Electrical Resistance ; LSC ; Liquid Scintillation Counting ; SCCS ; Scientific Committee on Consumer Safety ; EFSA ; European Food Safety Authority ; OECD ; Organisation for Economic Co-operation and Development
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：Complete
• 页码：101-107
• 全文大小：883 K
• 卷排序：38

文摘

An in vitro model of pig skin compromised by tape stripping has been investigated. Skin penetration and distribution of reference chemicals was established over 24 h. Although impaired, skin compromised using this model retained barrier capabilities. This skin model could be useful for human risk assessment of consumer products.