Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance
详细信息 查看全文
- 作者：Christopher D. Makinsona ; 1 ; Brian S. Tanakab ; 1 ; Tyra Lamara ; Alan L. Goldinb ; c ; agoldin@uci.edu" class="auth_mail ; Andrew Escayga ; aescayg@emory.edu" class="auth_mail
- 关键词：Scn8a ; Nav1.6 ; Scn1a ; Nav1.1 ; GEFS+ ; Dravet syndrome ; Voltage-gated sodium channel ; Lentivirus ; Cre recombinase
- 刊名：Neurobiology of Disease
- 出版年：August 2014
- 年：2014
- 卷：68
- 期：Complete
- 页码：16-25
- 全文大小：1160 K
文摘
- •
Hippocampal burst latency and occurrence are reduced in Scn8amed/+ mice after P20.
- •
The Scn8a-med mutation reduces burst discharges in a GEFS+ model of epilepsy.
- •
Cre-mediated hippocampal knockdown of Scn8a confers seizure resistance.
- •
Global inactivation of Scn8a in the adult mouse increases seizure thresholds.
- •
Selective targeting of SCN8A might be efficacious as a treatment for epilepsy.