Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells

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• 作者：Wei Liu^a ; Alon Rabinovich^b ; Yuval Nash^b ; ^d ; Dan Frenkel^b ; ^d ; Yuqiang Wang^c ; Moussa B.H. Youdim^a ; Orly Weinreb^a ; ^{worly@tx.technion.ac.il}
• 关键词：Cholinesterase inhibition ; Monoamine oxidase-A inhibition ; Multitarget drug ; Scopolamine mouse model ; Anti-inflammation
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：445-456
• 全文大小：953 K
• 卷排序：113

文摘

MT-031 is a novel hybrid molecule of rasagiline and rivastigmine. This anti-AD drug candidate is a brain AChE/BuChE and MAO-A inhibitor. MT-031 antagonized scopolamine-induced memory and cognitive impairments in mice. MT-031 exerted protection/anti-inflammation in scopolamine-induced mice. Anti-inflammatory effects of MT-031 were shown in anti-CD3 and LPS-activated cells.