Mitochondrial Cristae: Where Beauty Meets Functionality

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• 作者：Sara Cogliati¹ ; Jose A. Enriquez¹ ; ² ; Luca Scorrano³ ; ⁴ ; ^{luca.scorrano@unipd.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：cristae ; OXPHOS complexes and supercomplexes ; mitochondrial-shaping proteins
• 刊名：Trends in Biochemical Sciences
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：41
• 期：3
• 页码：261-273
• 全文大小：2245 K

文摘

Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under different physiological conditions. Recent discoveries have unveiled the relation between cristae shape and oxidative phosphorylation (OXPHOS) function, suggesting that membrane morphology modulates the organization and function of the OXPHOS system, with a direct impact on cellular metabolism. As a corollary, cristae-shaping proteins have emerged as potential modulators of mitochondrial bioenergetics, a concept confirmed by genetic experiments in mouse models of respiratory chain deficiency. Here, we review our knowledge of mitochondrial ultrastructural organization and how it impacts mitochondrial metabolism.