Down-regulation of adenosine A1 and A2A receptors in peripheral cells from idiopathic normal-pressure hydrocephalus patients
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- 作者：Martina Casatia ; b ; martina.casati@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Beatrice Arosioa ; c ; Cristina Gussagoa ; Evelyn Ferria ; b ; Lorenzo Magnia ; c ; Lara Assolaria ; c ; Valeria Scortichinia ; c ; Carolina Nania ; c ; Paolo Dionigi Rossic ; Daniela Maria ; c
- 关键词：Adenosine A2A receptor ; Adenosine A1 receptor ; Idiopathic normal-pressure hydrocephalus
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：361
- 期：Complete
- 页码：196-199
- 全文大小：271 K
文摘
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Pathophysiology of idiopathic normal-pressure hydrocephalus (iNPH) is still unknown.
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Venous and immune alterations seem to be present in iNPH.
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Adenosine receptors are involved in vascular protection and inflammatory modulation.
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We report a down-regulation of adenosine receptors expressions in iNPH patients.
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Ado system is altered in iNPH disease.