IKKα inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line

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• 作者：Martina Leopizzi^a ; ¹ ; Rossana Cocchiola^b ; ¹ ; Edoardo Milanetti^c ; Domenico Raimondo^d ; Laura Politi^b ; Cesare Giordano^e ; Roberto Scandurra^b ; Anna Scotto d'Abusco^b ; ^{anna.scottodabusco@uniroma1.it}
• 关键词：IKKα ; Maspin ; Osteosarcoma ; Glucosamine-derivatives ; Cell invasiveness
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：262
• 期：Complete
• 页码：19-28
• 全文大小：1810 K
• 卷排序：262

文摘

NCPA is a glucosamine derivative able to counteract inflammatory pathways. NCPA inhibits IKKα nuclear translocation inducing Maspin production. NCPA decrease β1 Integrin and MMP-9 and -13. NCPA inhibits cell migration in osteosarcoma cell line 143B.