Dynamic Changes in Chromatin Accessibility Occur in CD8⁺ T Cells Responding to Viral Infection

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• 作者：James P. Scott-Browne¹ ; Isaac F. L&oacute ; pez-Moyado¹ ; Sara Trifari¹ ; Victor Wong¹ ; Lukas Chavez¹ ; ⁴ ; Anjana Rao¹ ; ² ; ³ ; ⁶ ; ^arao@lji.org ; Renata M. Pereira¹ ; ⁵
• 刊名：Immunity
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：45
• 期：6
• 页码：1327-1340
• 全文大小：4208 K
• 卷排序：45

文摘

Examined chromatin accessibility in endogenous CD8+ T cells during viral infection Many changes from naive T cells are stably maintained in differentiated cell types Groups of differentially accessible regions are shared between different subsets Exhaustion-specific accessible regions are enriched for NFAT and Nr4a binding sites