Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology
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- 作者：Rainbo Hultman1 ; Stephen D. Mague1 ; Qiang Li1 ; Brittany M. Katz1 ; Nadine Michel1 ; Lizhen Lin7 ; Joyce Wang1 ; Lisa K. David1 ; Cameron Blount1 ; Rithi Chandy1 ; David Carlson6 ; Kyle Ulrich6 ; Lawrence Carin6 ; David Dunson5 ; Sunil Kumar1 ; Karl Deisseroth8 ; Scott D. Moore1 ; Kafui Dzirasa1 ; 2 ; 3 ; 4 ; kafui.dzirasa@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：oscillations ; synchrony ; chronic stress ; major depressive disorder ; neural networks
- 刊名：Neuron
- 出版年：2016
- 出版时间：20 July 2016
- 年：2016
- 卷：91
- 期：2
- 页码：439-452
- 全文大小：2579 K
文摘
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Prefrontal cortex (PFC) oscillations synchronize with ultraslow limbic dynamics
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PFC unit firing signals the synchronization state of amygdala (AMY) and ventral tegmental area (VTA)
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Chronic stress selectively disrupts PFC-dependent regulation of AMY-VTA synchrony
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PFC to AMY circuit stimulation recovers normal network function and behavior