Are rapidly growing cancers more lethal?

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• 作者：Hans-Olov Adami^a ; ^b ; ^c ; ^{hadami@hsph.harvard.edu} ; Peter Csermely^d ; Daniel V. Veres^d ; ^e ; Louise Emilsson^a ; ^c ; ^f ; Magnus Lø ; berg^a ; ^g ; Michael Bretthauer^a ; ^g ; ¹ ; Mette Kalager^a ; ^g ; ¹
• 关键词：Breast cancer ; Cancer stem-like cells ; Cervical cancer ; Colorectal cancer ; Dormancy ; Metastasis ; Lethality ; Signalling networks ; Tumour growth
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：210-214
• 全文大小：436 K
• 卷排序：72

文摘

The view that rapidly growing tumors are more lethal has remained almost axiomatic for decades. Rapid growth and metastases formation are often different outcomes of complex integrated molecular events. In humans interval cancers are more rapidly growing than cancers unaffected by screening. Cancers of the breast, cervix and large bowel, do not support the theory that rapidly growing cancers are more lethal. Existing evidence provide no support for treating interval cancers more aggressively than non-interval cancers.