Renal-cell carcinoma risk estimates based on participants in the prostate, lung, colorectal, and ovarian cancer screening trial and national lung screening trial
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- 作者：Yair Lotan ; M.D.a ; yair.lotan@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Jose A. Karam ; M.D.b ; Shahrokh F. Shariat ; M.D.c ; Amit Gupta ; M.D.d ; Morgan Roupret ; M.D.e ; f ; Karim Bensalah ; M.D.g ; Vitaly Margulis ; M.D.a
- 关键词：Renal-cell carcinoma ; Risk factors ; Sex ; Risk stratification
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：34
- 期：4
- 页码：167.e9-167.e16
- 全文大小：190 K
文摘
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Data were extracted from PLCO and NLST to stratify the risk of RCC by sex, race, age at inclusion, obesity, and smoking status.
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Overall, 701/154,118 and 190/53,242 RCCs were detected in PLCO and NLST, respectively.
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Incidence rates were higher in men (PLCO: 0.56 vs. 0.28/1000 person y, NLST: 0.73 vs. 0.35/1000 person y; both with P<0.0001).
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In the PLCO, male sex, age>60 years, obesity, and intensity of smoking were associated with higher risk of developing RCC.
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In the NLST, sex and morbid obesity increased the risk for RCC but age, ethnicity, and smoking intensity were not predictors.