Ex聽vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract
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- 作者：Hirotaka Kanoha ; 1 ; 3 ; Takayuki Kuraishia ; b ; 2 ; 3 ; takayuki.kuraishi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Li-Li Tonga ; Ryo Watanabea ; Shinji Nagatac ; Shoichiro Kurataa ; kurata@mail.pharm.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Drosophila ; Innate immunity ; Sterile inflammation ; Toll pathway ; Danger signals
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：13 November 2015
- 年：2015
- 卷：467
- 期：2
- 页码：400-406
- 全文大小：1271 K
文摘
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The Drosophila larva-derived tissue extract activates the Toll pathway.
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The extract activates Toll without Spz or bacterial components.
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Genome-wide RNAi screening revealed damage-related signaling factors.