Screening and identification of molecular targets for cancer therapy

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• 作者：Alshaimaa Abdelmoez^a ; ^b ; Dé ; bora C. Coraç ; a-Huber^c ; Gudrun C. Thurner^b ; Paul Debbage^b ; Peter Lukas^a ; Sergej Skvortsov^a ; Ira-Ida Skvortsova^a ; ^{ira.skvortsova@i-med.ac.at}
• 关键词：Cancer ; Cellular membranes ; Proteomics ; Target ; Signaling pathways ; Cancer stem cells
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：387
• 期：Complete
• 页码：3-9
• 全文大小：1262 K
• 卷排序：387

文摘

Novel targeted therapeutics can help to combat tumor resistance to anti-cancer treatment resulting in recurrence development. Carcinoma cell membranes represent a large potential source of druggable therapeutic targets. Proteomics is a promising tool for developing potential therapeutic targets. Proteome-based evaluation of membrane fractions helps to detect potential therapeutic targets.