Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth
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- 作者：Davide D&rsquo ; Amico1 ; 10 ; Laura Antonucci1 ; 7 ; 10 ; Laura Di Magno6 ; Sonia Coni1 ; Giulia Sdruscia6 ; Alberto Macone2 ; Evelina Miele6 ; Paola Infante6 ; Lucia Di Marcotullio1 ; 6 ; 7 ; Enrico De Smaele3 ; Elisabetta Ferretti3 ; Laura Ciapponi4 ; Felice Giangaspero5 ; John R. Yates III9 ; Enzo Agostinelli2 ; 7 ; Beatrice Cardinali8 ; Isabella Screpanti1 ; 7 ; Alberto Gulino1 ; 6 ; Gianluca Canettieri1 ; gianluca.canettieri@uniroma1.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2015
- 出版时间：12 October 2015
- 年：2015
- 卷：35
- 期：1
- 页码：21-35
- 全文大小：3545 K
文摘
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Hh controls polyamine metabolism and medulloblastoma growth via ODC biosynthesis
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Sufu binds and stabilizes CNBP to regulate ODC translation
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AMPK phosphorylates and activates CNBP in response to Hh stimulation
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Targeting this non-canonical axis inhibits medulloblastoma growth