19(4 鈫?3)-abeo-abietane diterpenoids from Scrophularia dentata Royle ex Benth

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• 作者：Liuqiang Zhang^a ; ¹ ; Dawei Zhang^b ; ¹ ; Qi Jia^a ; Rui Wang^a ; Gaawe Dorje^c ; Zhili Zhao^a ; Fujiang Guo^a ; Yifu Yang^b ; ^{yangyifu@mail.shcnc.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Yiming Li^a ; ^{ymlius@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Scrodentoid ; Artefact ; Immunosuppressive effects
• 刊名：Fitoterapia
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：106
• 期：Complete
• 页码：72-77
• 全文大小：579 K

文摘

Five 19(4 → 3)-abeo-abietane diterpenoids, scrodentoids A–E (1–5), were isolated from the whole plant of Scrophularia dentata. Planar structures of scrodentoids A–E were elucidated mainly by using 1D, 2D NMR and MS data. The absolute configurations of compounds 1 and 2 were established using X-ray crystallographic analysis. The absolute configurations of other compounds were confirmed using HPLC-UV/CD detection. The immunosuppressive effects of compounds 1–5 were studied using a ConA-induced splenocyte proliferation model. These compounds significantly inhibited ConA-induced splenocyte proliferation, with IC₅₀ values in the range of 3.49–133.86 渭M. Compounds 1–5 (IC₅₀ > 10 渭M) showed no discernible cytotoxic activity against B16 or MCF-7 cells.