Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage
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- 作者：Brian McDonagh1 ; Siobhan M. Scullion1 ; Aphrodite Vasilaki ; Natalie Pollock ; Anne McArdle ; Malcolm J. Jackson ; m.j.jackson@liverpool.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：CP ; 3-carboxy-proxyl ; CPH ; 1-Hydroxy-3-carboxy-2 ; 2 ; 5 ; 5-tetramethylpyrrolidine ; Nav1.5 ; Voltage gated sodium channel isoform ; NCAM ; Neural cell adhesion molecule ; NEM ; N-ethylmaleimide ; NMJ ; Neuromuscular junction ; NOX2 ; NAD(P)H oxidase 2 ; Prdx ; Peroxiredoxin ; SOD1 ; CuZn superoxide dismutase
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：27-35
- 全文大小：1923 K
文摘
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Sarcopenia is accompanied by disruption of motor neurons and neuromuscular junctions.
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Old nerves have decreased axon numbers and diameter.
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EPR studies showed increased superoxide/peroxynitrite activities in old nerves.
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Old nerves show changes in redox sensitive proteins without major oxidative damage.
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Results indicate altered redox signalling pathways in nerves from old mice.