Characterisation of the TNF superfamily members CD40L and BAFF in the small-spotted catshark (Scyliorhinus canicula)
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- 作者：Ronggai Lia ; 1 ; Anthony K. Redmondb ; Tiehui Wanga ; Steve Birdc ; Helen Dooleya ; h.dooley@abdn.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Chris J. Secombesa
- 关键词：CD40L ; BAFF ; TNFSF ; Shark ; Cartilaginous fish
- 刊名：Fish & Shellfish Immunology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：47
- 期：1
- 页码：381-389
- 全文大小：2265 K
文摘
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CD40L and BAFF were cloned from the small-spotted catshark Scyliorhinus canicula.
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Both catshark CD40L and BAFF are highly expressed in shark immune tissues.
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CD40L and BAFF expression levels are altered following in vitro stimulation of catshark PBLs.
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CD40L levels correlate with those of TCR伪 in various catshark tissues.
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Cartilaginous fish CD40L and BAFF carry insertions that may alter their receptor binding site.