Mononuclear copper(II) complexes with a tetradentate pyrazole based ligand: Syntheses, structures, DNA binding study and antimicrobial activity

详细信息    查看全文

• 作者：Ankita Solanki ; Sujit Baran Kumar ; Ankita A. Doshi ; C. Ratna Prabha
• 关键词：Tetradentate ; Pseudohalides ; Copper(II) complexes ; Structure ; DNA binding ; Antibacterial activity
• 刊名：Polyhedron
• 出版年：2013
• 出版时间：31 October, 2013
• 年：2013
• 卷：63
• 期：Complete
• 页码：147-155
• 全文大小：1533 K

文摘

A new tetradentate N₄-coordinate ligand, N,N-diethyl-N¡ä,N¡ä-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)ethane-1,2-diamine (dbdmp), and its mononuclear copper(II) complexes [Cu(X)(dbdmp)]Y, where X = N₃^?, NCS^?, NCO^? and Y = ClO₄^?, PF₆^? and BF₄^?, have been synthesized and characterized by microanalysis, physico-chemical and spectroscopic methods. The crystal structures of the four complexes [Cu(N₃)(dbdmp)]ClO₄ (1) [Cu(NCS)(dbdmp)]ClO₄ (4), [Cu(NCS)(dbdmp)]PF₆ (5) and [Cu(NCO)(dbdmp)]ClO₄ (7) were solved by single crystal X-ray diffraction studies and showed that all the complexes have distorted trigonal bipyramidal geometries. Interaction of CT-DNA with complexes 1-6 were examined by spectroscopic titration and fluorescence techniques and showed that the complexes have strong interactions with CT-DNA. The antimicrobial activities of complexes 1-6 were studied by the dilution method against Gram positive (Bacillus subtilis) and Gram negative (Escherichia coli) strains and showed the complete inhibition of the tested strains by the complexes.