Association among retinol-binding protein 4, small dense LDL cholesterol and oxidized LDL levels in dyslipidemia subjects

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• 作者：Jia Wu¹ ; Yong-hui Shi¹ ; Dong-mei Niu ; Han-qing Li ; Chun-ni Zhang ; Jun-jun Wang ; ^{Wangjj9202@163.com}
• 关键词：RBP4 ; retinol-binding protein 4 ; sdLDL-C ; small dense low-density lipoprotein cholesterol ; ox-LDL ; oxidized low-density lipoprotein cholesterol ; LDL ; low-density lipoprotein ; sdLDL ; small dense LDL ; CVD ; cardiovascular disease ; CETP ; cholesterol ester tra
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：45
• 期：9
• 页码：619-622
• 全文大小：150 K

文摘

Objectives

To investigate retinol-binding protein 4 (RBP4), small dense low-density lipoprotein cholesterol (sdLDL-C) and oxidized low-density lipoprotein (ox-LDL) levels and their associations in dyslipidemia subjects.

Design and methods

We determined RBP4, sdLDL-C, ox-LDL levels in 150 various dyslipidemia subjects and 50 controls. The correlation analysis and multiple linear regression analysis were performed.

Results

The RBP4, sdLDL-C and ox-LDL levels were found increased in various dyslipidemia subjects. The sdLDL-C levels were positively correlated with RBP4 (r = 0.273, P = 0.001) and ox-LDL (r = 0.273, P = 0.001). RBP4 levels were also correlated with ox-LDL (r = 0.167, P = 0.043). The multiple regression analysis showed that only sdLDL-C was a significant independent predictor for RBP4 (¦Â coefficient = 0.219, P = 0.009; adjusted R² = 0.041) and ox-LDL (¦Â coefficient = 0.253, P = 0.003; adjusted R² = 0.057) levels, respectively.

Conclusions

The independent associations of sdLDL-C with RBP4 and ox-LDL were observed in dyslipidemia subjects. RBP4 may play an important role in lipid metabolism of atherosclerosis, particularly in formation of sdLDL.