Antiparasitic effect of dietary Romet?30 (SDMX-OMP) against ciliate Cryptocaryon irritans infection in the red sea bream Pagrus major and tiger puffer Takifugu rubripes

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• 作者：Fumi Kawano^a ; Noritaka Hirazawa^b ; ^{n-hiraza@nissui.co.jp} ; Kjersti Gravningen^c ; Jan Oppen Berntsen^d
• 关键词：Sulfadimethoxine&ndash ; ormetoprim ; Romet® ; 30 ; Cryptocaryon irritans ; Therapeutic effect
• 刊名：Aquaculture
• 出版年：2012
• 出版时间：21 May, 2012
• 年：2012
• 卷：344-349
• 期：Complete
• 页码：35-39
• 全文大小：364 K

文摘

We investigated the effects of dietary Romet?30 (sulfadimethoxine-ormetoprim (SDMX-OMP)) on Cryptocaryon irritans infection in red sea bream Pagrus major and tiger puffer Takifugu rubripes. In Experiment I, 100 % mortality of P. major due to C. irritans infection was observed at 10 days and 21 days after exposure to theronts (infective stage) in the a control group without Romet?30 and the group treated with 50 mg Romet?30/kg body weight (BW)/day for 14 days, respectively. Thus, mortality in the treated group was markedly delayed compared with that in the control group. In Experiment II, 100 % mortality of P. major in the control group due to C. irritans infection was recorded at 11 days after exposure to theronts. In contrast, mortality due to parasite infection was not observed in the group treated with Romet?30 at 50 mg/kg BW/day for 14 days, and no parasites were found in any surviving fish after 33 days exposure. In addition, the number of parasites on the gills of T. rubripes treated with 50 mg Romet?30/kg BW/day for 14 days was significantly lower than that in the control group after 16 days exposure. These results show that in-feed Romet?30 at 50 mg/kg BW/day for 14 days had antiparasitic and therapeutic effects against C. irritans in both P. major and T. rubripes. Thus, dietary Romet?30 could be useful for controlling C. irritans infection.