Supercritical extract of Seabuckthorn Leaves (SCE200ET) inhibited endotoxemia by reducing inflammatory cytokines and nitric oxide synthase 2 expression
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- 作者：Bindhya Jayashankar ; K.P. Mishra ; kpmpgi@rediffmail.com" class="auth_mail ; L. Ganju ; S.B. Singh
- 关键词：Endotoxin ; Supercritical carbon dioxide extract (SCE) ; Cytokines ; Nitric oxide ; CD40
- 刊名：International Immunopharmacology
- 出版年：May 2014
- 年：2014
- 卷：20
- 期：1
- 页码：89-94
- 全文大小：560 K
文摘
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Endotoxins from infectious organisms lead to sepsis, a systemic inflammatory response.
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We have identified a plant extract from Seabuckthorn (SCE200ET) as a potent agent for the treatment of endotoxemia.
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Fractionation of the extract by RP-HPLC led to identification of isorhamnetin, as bioactive component.
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SCE200ET and Isorhamnetin inhibited LPS induced inflammatory mediators.
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SCE200ET and Isorhamnetin could be potential therapeutic agents for endotoxin induced sepsis.