Hyperbranched polyglycerols on the nanometer and micrometer scale

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• 作者：Dirk Steinhilber ; Sebastian Seiffert ; John A. Heyman ; Florian Paulus ; David A. Weitz ; Rainer Haag
• 关键词：Biocompatibility ; Cell encapsulation ; Hydrogel ; Microsphere ; Nanoparticle
• 刊名：Biomaterials
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：32
• 期：5
• 页码：1311-1316
• 全文大小：1334 K

文摘

We report the preparation of polyglycerol particles on different length scales by extending the size of hyperbranched polyglycerols (3 nm) to nanogels (32 nm) and microgels (140 and 220 μm). We use miniemulsion templating for the preparation of nanogels and microfluidic templating for the preparation of microgels, which we obtain through a free-radical polymerization of hyperbranched polyglycerol decaacrylate and polyethylene glycol-diacrylate. The use of mild polymerization conditions allows yeast cells to be encapsulated into the resultant microgels with cell viabilities of approximately 30 % .