5Lipoxygenase is upregulated in brain aging and Alzheimer’s disease.
5Lipoxygenase acts as an endogenous modulator of Aβ formation in vitro and in vivo.
5Lipoxygenase modulates the four components of the γ-secretase complex at the transcription levels without affecting Notch signaling.
5Lipoxygenase has a pleiotropic effect on the entire spectrum of the Alzheimer’s disease phenotype.
5Lipoxygenase is a viable therapeutic target for Alzheimer’s disease.