Methyltransferase blockade with dAza hampered bone metastasis outgrowth.
dAza decreased SPARC and Endothelin 1 at the invasive front of bone metastasis.
DNA methyltransferases affected microenvironment stimuli of bone metastasis via Twist.
miRNAs impaired the expression of SPARC and Endothelin 1.
A therapeutic strategy would be to modify the osteogenic niche increasing latency.