Simultaneous tongue and liver carcinogenesis in mice by oral NDEA administration
Restriction of both carcinogenesis by EGCG and TF at early pre-malignant stages
The mechanisms of carcinogenesis and restriction were similar in both the organs.
Changes in proliferation/apoptosis and CD44 + ve population were seen in the events.
The self renewal Wnt and Hedgehog pathways were modulated during the restriction.