CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis
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- 作者：Timothy W. Pharesa ; pharest@ccf.org" class="auth_mail" title="E-mail the corresponding author ; Krista D. DiSanoa ; b ; disanok@ccf.org" class="auth_mail" title="E-mail the corresponding author ; Stephen A. Stohlmana ; stohlms2@ccf.org" class="auth_mail" title="E-mail the corresponding author ; Benjamin M. Segalc ; bmsegal@med.umich.edu" class="auth_mail" title="E-mail the corresponding author ; Cornelia C. Bergmanna ; bergmac@ccf.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Central nervous system ; Neuroimmunology ; CXCL13 ; B cells ; Antibody secreting cells ; Memory B cells
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：128-139
- 全文大小：2943 K
文摘
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Migration of naïve/early-activated B cells to the CNS is independent of CXCL13.
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CXCL13 promotes CNS accumulation of isotype-switched B cells.
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CXCL13 dependent GC formation is not required for serum neutralizing antibodies.