Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis

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• 作者：Brian K. Chung^a ; ^b ; ^c ; ^d ; Bardia T. Guevel^a ; ^b ; Gary M. Reynolds^a ; ^b ; D.B.R.K. Gupta Udatha^c ; ^e ; ^f ; Eva Kristine Klemsdal Henriksen^c ; ^d ; ^e ; ^f ; Zania Stamataki^a ; ^b ; Gideon M. Hirschfield^a ; ^b ; ^{g.hirschfield@bham.ac.uk} ; Tom Hemming Karlsen^c ; ^d ; ^e ; ^f ; ^{t.h.karlsen@medisin.uio.no} ; Evaggelia Liaskou^a ; ^b
• 关键词：Primary biliary cholangitis ; Primary sclerosing cholangitis ; Antibody-secreting B cells ; Autoimmunity ; Auto-antibodies ; Protein arrays ; Biomarkers
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：77
• 期：Complete
• 页码：45-54
• 全文大小：2007 K
• 卷排序：77

文摘

Disease restricted auto-antibody signatures can potentially inform disease pathophysiology. Liver-infiltrating antibody-secreting B cells (ASCs) are reduced in PSC compared to PBC. Cultured liver-infiltrating ASCs in PSC and PBC produce auto-antibodies. Liver-infiltrating ASCs in PBC secrete auto-antibodies to HK1 and PDC-E2. Auto-antibodies from liver-infiltrating ASCs in PSC share reactivity to novel antigen targets.