Activation of zinc-requiring ectoenzymes by ZnT transporters during the secretory process: Biochemical and molecular aspects
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- 作者：Taiho Kambe ; kambe1@kais.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Taka-aki Takeda ; Yukina Nishito
- 关键词：Zinc-requiring ectoenzymes ; ZnT/SLC30A ; Early secretory pathway ; Tissue-nonspecific alkaline phosphatase ; Chaperone
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：611
- 期：Complete
- 页码：37-42
- 全文大小：573 K
文摘
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Various ectoenzymes require zinc within their active sites for activation.
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Such zinc-requiring ectoenzymes may capture zinc during the secretory process.
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These enzymes are interesting due to their potential as therapeutic targets.
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Some ZnTs play roles in their activation through an elaborate two-step mechanism.
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Zinc chaperone may function in the facilitated transfer of cytosolic zinc to ZnTs.