GAPDH binds Akt to facilitate cargo transport in the early secretory pathway
详细信息 查看全文
- 作者：Ellen J. Tisdalea ; etisdale@med.wayne.edu" class="auth_mail" title="E-mail the corresponding author ; Nikunj K. Talatia ; Cristina R. Artalejoa ; Assia Shishevab
- 关键词：aPKC ; Atypical PKC ; endo H ; endoglycosidase H ; ER ; endoplasmic reticulum ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; NGS ; normal goat serum ; NRK ; normal rat kidney ; pAkt ; phosphoAkt ; VSV-G ; vesicular stomatitis virus G-protein ; VTCs ; vesicular tubular clusters
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：10 December 2016
- 年：2016
- 卷：349
- 期：2
- 页码：310-319
- 全文大小：1561 K
文摘
- •
Pro234Ser substitution in GAPDH arrests endoplasmic reticulum to Golgi transport.
- •
GAPDH (Pro234Ser) causes Golgi fragmentation with no observable affect on the microtubule network.
- •
GAPDH (Pro234Ser) does not bind Akt.
- •
GAPDH-Akt required for anterograde transport in the early secretory pathway.