Protein O-mannosylation in the early secretory pathway
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文摘

O-Mannosylation initiates at the translocon complex in the endoplasmic reticulum (ER).

O-Man glycans can mark and exclude unfavorable folding intermediates (UPOM).

O-Mannosylation is an integral part of the interlinked ER protein homeostasis network.

New insights from high throughput MS-based glycoproteomics are discussed.

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