Synthesis of all four nucleoside-based ¦Â-amino acids as protected precursors for the synthesis of polyamide-DNA with alternating ¦Á-amino acid and nucleoside-¦Â-amino acids

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• 作者：Seema Bagmare ; Manojkumar Varada ; Anjan Banerjee ; Vaijayanti A. Kumar ; ^{va.kumar@ncl.res.in}
• 关键词：Neutral DNA analogues ; Nucleoside-¦Â amino acids ; Antisense therapeutics
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：21 January, 2013
• 年：2013
• 卷：69
• 期：3
• 页码：1210-1216
• 全文大小：525 K

文摘

A simple approach is described for the synthesis of all four orthogonally protected nucleoside-¦Â-amino acids from commercially available starting materials. Synthesis of a model tetrameric DNA sequence in 5¡ä¨C3¡¯direction employing trityl strategy and glycine as ¦Á-amino acid alternating with nucleoside-¦Â amino acids is described.