Three-step drug extraction from a single sub-millimeter segment of hair and nail to determine the exact day of drug intake
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- 作者：Kenji Kuwayama ; kuwayama@nrips.go.jp" class="auth_mail" title="E-mail the corresponding author ; Hajime Miyaguchi ; Yuko T. Iwata ; Tatsuyuki Kanamori ; Kenji Tsujikawa ; Tadashi Yamamuro ; Hiroki Segawa ; Hiroyuki Inoue
- 关键词：Hair ; Nail ; LC/MS ; Drug ; Distribution
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：948
- 期：Complete
- 页码：40-47
- 全文大小：1127 K
文摘
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We prepared accurate 0.4-mm hair and 0.2-mm nail segments using a tissue slicer.
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Those correspond to their respective growth rates of 1–2 days.
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Sonication was an efficient drug extraction method from a sub-millimeter segment.
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Drug distributions in a single hair and a nail block were measured at day levels.